Transforming lives by accelerating innovation in cardiometabolic health

About

Obesity and its associated complications comprise some of the world’s most pressing health issues.

We created Verdiva Bio to accelerate the development of differentiated medicines that address the significant unmet medical needs in this space.

Verdiva Bio is developing next-generation medicines with the goal of helping people living with obesity, cardiometabolic diseases, and related conditions achieve better health outcomes through more convenient and patient-friendly treatments.

Our pipeline is built around rationally engineered peptides designed for purpose. Our lead program, VRB-101, is an oral formulation of ecnoglutide, a cAMP-biased, GLP-1 peptide analog, which is currently in Phase 2 clinical development as a once-weekly treatment of obesity. Phase 1 results demonstrated promising efficacy and supported the potential for once-weekly oral dosing, enabled by a proprietary oral absorption enhancer, T2026, designed to support reliable delivery and scalable manufacturing.

Alongside our GLP-1 program, Verdiva is advancing a portfolio of amylin-based product candidates designed to support meaningful weight loss and healthier weight management. These programs include both oral and injectable product candidates, as well as additional undisclosed candidates, expanding our pipeline across complementary mechanisms with the aim to address obesity and related metabolic diseases.

Pipeline

Potential best-in-class therapies for cardiometabolic conditions

Program
MoA
Dosing
Discovery
Preclinical
Phase 1
Phase 2
Phase 3
VRB-101
(Oral)
GLP-1
Once-weekly peptide
Discovery
Preclinical
Phase 1
Phase 2
Phase 3
Ph 2-ongoing

VRB-101 (Oral)

VRB-101, an oral formulation of ecnoglutide, is a cAMP-biased GLP-1 analog currently in clinical development as a once-weekly treatment of obesity

VRB-103
(Oral)
Amylin
Once-weekly peptide
Discovery
Preclinical
Phase 1
Phase 2
Phase 3
IND-enabling

VRB-103 (Oral)

VRB-103 is an oral, amylin-selective receptor analog in preclinical development for once-weekly treatment of obesity either as a monotherapy or in combination with oral GLP-1 therapy

VRB-101 + VRB-103
(Oral)
Amylin + GLP-1
Once-weekly or daily
Discovery
Preclinical
Phase 1
Phase 2
Phase 3
IND-enabling

VRB-101 + VRB-103 (Oral)

Verdiva Bio is evaluating the optimal combination of VRB-101 and VRB-103 as a once-daily or once-weekly therapy for the treatment of obesity

VRB-101 + VRB-102
(Injectable)
Amylin + GLP-1
Once-weekly peptide(s)
Discovery
Preclinical
Phase 1
Phase 2
Phase 3
IND-enabling

VRB-101 + VRB-102 (Injectable)

VRB-102 is an amylin receptor analog in preclinical development designed for co-formulation with incretins and for once-weekly injection

VRB-104
(Undisclosed)
Undisclosed
Once-weekly peptide(s)
Discovery
Preclinical
Phase 1
Phase 2
Phase 3
IND-enabling

VRB-104 (Undisclosed)

VRB-104 is an undisclosed, once-weekly next-generation peptide in preclinical development

To view the latest publications and scientific developments, visit our Publications & Presentations section

Team

Leadership
Board

Leadership

Khurem Farooq

Chief Executive Officer

Jane Hughes

President, R&D

Mohamed Eid, MD

Chief Medical Officer

Ashley Taylor

Chief Technology Officer

Tapan Maniar

Chief Business Officer

Andrew Prosser

SVP, Head of Finance

Elaine Johnston

General Counsel

Weidong Zhong

Chief Strategy Officer

Board

Mark Pruzanski, MD

Board Chair

Khurem Farooq

 Chief Executive Officer

Wouter Joustra

General Partner, Forbion

Brett Zbar, MD

Managing Director and Global Head of Life Sciences, General Atlantic

Laura Stoppel

Partner at RA Capital Management, L.P.

Carl Gordon

Managing Partner, OrbiMed

Graham Walmsley, MD

Co-Founder & Managing Partner at Logos Capital

Investors

Forbion.
GENERAL ATLANTIC
RACAPITAL
orbimed
LOGOS CAPITAL
Lilly Asia Ventures
LYFE CAPITAL

News

24 February 2026

Verdiva Bio Announces Completion of Enrollment for EVOLVE-2 Phase 2b Study of VRB-101, a potential Once-Weekly Oral GLP-1 Peptide Analog in Individuals with Obesity

22 September 2025

Verdiva Bio Selected by Fierce Biotech as a “Fierce 15” Winner of 2025

1 September 2025

Verdiva Bio to present data on once-weekly potential of its investigational oral obesity candidates at 61st EASD Annual Meeting

21 June 2025

Verdiva Bio to present new data highlighting once-weekly potential of its investigational oral obesity candidates at the ADA 85th Scientific Sessions

4 June 2025

Verdiva Bio attending American Diabetes Association 20-23rd June

9 January 2025

Verdiva Bio, a New Clinical-Stage Cardiometabolic Company, Launches with Over $410M in Series A Financing to Advance Next-Generation Therapies

Contact

Do you have questions or want to learn more about our transformative work?

Reach out to us using the form here. We value your input and are excited to engage with like-minded individuals, potential partners, and collaborators who share our passion for innovation in metabolic disease research.